Colleen Scott

Image of Colleen Scott

Colleen Scott

Assistant Professor

B.S. Auburn University, 1998
Ph.D. University of Pittsburgh, 2005

Email

Hand Lab 3325

(662) 325-8315

Website CV

Research Interests

scientific imageOrganic Polymeric Materials – Thermoplastics & Conducting Plastics, Chemical & Biological Sensors

Polymers have a range of application that exceeds any other material type; applications include everything from adhesives, coatings, and industrial fabrics to structural components in the construction, biomedical, and aerospace industry.Research interest in the Scott group is focused on the design, synthesis, and characterization of advanced organic materials utilizing the tools of organic chemistry to create macromolecules with interesting properties and functions.

A major goal of ours is to develop new materials from an “intelligent design” approach by designing materials with specific properties based on organic groups.  For example, we can tune conducting polymers to behave as n-type materials or emissive materials for OFETs and OLEDS or donor-acceptor low band gap materials for photovoltaic applications by changing functional groups and/or co-monomers. We can also implement side groups on polymers that will allow them to behave as a molecular switch for sensing applications. We also synthesize polymers for batteries and capacitors application.

scientific imageSustainability is a major focus in science, especially for the preparation of materials. Our group explores synthetic methods to prepare polymers from raw materials that are cheap and/or renewable for the purpose of manufacturing high performance materials. We are currently exploring organic precursors that can be obtained from lignin-based source to produce new biodegradable thermoplastics. We are also investigating a new design in developing new high temperature resistant materials.

Another area of interest in the Scott group is in the preparation of organic thin films formed by chemical transformations of macromolecules on the surface of various substrates. Our interest is to elucidate the molecular origins of the self-assembly processes in order to control the supramolecular organization of organic molecules and macromolecules. Chemists and materials scientists are particularly interested in developing new methodologies that allow for the "controlled" synthesis of large supramolecular assemblies with well-defined structures. Such assemblies are ubiquitous in nature (e.g. cell membranes, liquid crystals, proteins, etc.) and typically form spontaneously under the influence of forces that are poorly understood.

scientific imageOrganic Small Molecules – Chemical & Biological Sensors from sustainable synthesis of organosilicon compounds.

We have developed silicon-containing small molecules, which can be modified for the detection of selective analytes, or converted to a polymeric materials for application in biological imaging and chemo- and biosensing. We have been investigating the preparation of these materials using the C-H activation reaction as a sustainable method of conducting organic synthesis.

Work in the Scott lab is highly interdisciplinary; consequently students and postdocs are exposed to wide variety of equipment and characterization techniques for organic synthesis, thin films, polymers, and biomaterials.

Publications

  1. Chuangjun Liu, Quinn A. Best, Brian Suarez, Jack Pertile, Matthew E. McCarroll, Colleen N. Scott*, Cycloalkyl-AminoMethylRhodamines: pH Dependent Photophysical Properties Tuned by Cycloalkane Ring Size, J Fluoresc 2015, 25, 231–237.
  2. Bojan Mitrovic, Stephanie Eastwood, Gary Kinsel and Colleen Scott* “Stimuli Response of Cationic Polymer Brush Prepared by ATRP: Application in Peptide Fractionation" Polymer, 2014, 55, 3551–3556.
  3. Milind Bisen and Colleen Scott* “Synthesis and Optoelectronic Properties of a Low Band-Gap Co-Polymer Derived from Silole and Diketopyrrolopyrrole (DPP)” Macromolecules 2014, 47, 8196−8202.
  4. Bojan Mitrovic, Stephanie Eastwood, VenNey Wong, Daniel Dyer, Gary Kinsel and Colleen Scott* “Peptide/Protein Separation with Cationic Polymer Brush Nanosponges for MALDI-MS Analysis”, Langmuir 2013, 29, 696−700.
  5. Quinn Best, Narsimha Sattenapally, Daniel Bush, Daniel J. Dyer, Matthew McCarroll, and Colleen Scott.*  “pH-Dependent Si-Fluorescein Hypochlorous Acid Fluorescent Probe: Spirocycle Ring-Opening and Excess Hypochlorous Acid-Induced Chlorination”, J. Am. Chem. Soc., 2013, 135 (36), 13365–13370.
  6. Quinn A. Best, Chuangjun Liu, Paul D. van Hoveln, Matthew E. McCarroll, Colleen N. Scott*. “AnilinoMethylRhodamines: pH Sensitive Probe with Tunable Photophysical Properties by Substituent Effects”, J. Org. Chem., 2013, 78, 10134−10143.
  7. Sattenapally, N., Best, Q., Weerasinghe, K., Liu, C., Wang, L., Scott, C*. “Silicon Analogues of Fluorescein as Long Wavelength Fluorescent Probes for the Detection of Fluoride Anion” in revision.
  8. Colleen N. Scott* and Craig S. Wilcox. “A Mild Synthesis of Unsymmetrical Bis-Alkoxysilanes through Catalyzed Alcoholysis of Hydridosilanes Containing C-C Multiple Bonds and Aryl Halides.” J. Org. Chem. 2010, 75, 253–256.
  9. Scott, C. N.; Wilcox, C. S*. “A Mild Synthesis of Unsymmetrical Bis-Alkoxysilanes through Catalyzed Alcoholysis of Hydridosilanes.” Synthesis 2004, 16, 2273.
  10. Kar, S.; Lefterov, I. M.; Wang, M.; Lazo, J. S.; Scott, C. N.; Wilcox, C. S.; Carr, B. I. “Binding and Inhibition of Cdc25 Phosphatases by Vitamin K Analogs.” Biochemistry 2003, 42, 10490-10497.

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