Two Tales of Heterocyclic Chemistry Research at an Undergraduate Research Institution

Friday, March 1, 2019

Larry Yet

Chemistry Department

University of South Alabama

Reception: 3:00PM Hand 1135

Seminar: 3:30PM Hand 1144


Productive research output for students in a primarily undergraduate teaching and research institution can be particularly challenging at times.  The author has learnt over time that teaching undergraduate students’ research is not the same as teaching chemistry research assistants in industry with bachelor’s degrees on how to have productive research careers.  Some lessons have revealed some of the techniques to make undergraduate research productive and fun.  Penicinoline, a new pyrrolyl 4-quinolone alkaloid with an unprecedented ring system isolated from a mangrove endophytic fungus showed potent in vitro cytotoxicity.  Heterocyclic phosphorus ligands have been employed in various metal-catalyzed cross-coupling reactions.  The syntheses of heterocyclic natural product analogs and heterocyclic phosphorus ligands employed in Suzuki-Miyaura cross-coupling reactions will be showcased as examples of what motivated undergraduate student researchers can accomplish.

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