Spontaneous Resolution of Enantiomers During the Production of 2-Imino-5-Phenyl-4-Oxazolidinone

Friday, January 26, 2018

Dr. Peter Bonk

Reactive Intermediates, LLC

Hand Lab 1144,  3:30 PM


Abstract:  During the production of racemic 2-Imino-5-Phenyl-4-Oxazolidinone (Pemoline), spontaneous resolution of enantiomers was observed.  Pemoline of > 92% enantiomeric excess could be obtained from completely racemic starting materials.  The conditions required for this rare (and probably underreported) chemical behavior will be discussed. 

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