Scope and Mechanistic Studies of the Ruthenium-Catalyzed Dehydrative C-H Coupling Reactions with Alcohols and Carbonyl Compounds

Friday, November 9, 2018

Dr. Chae Yi

Department of Chemistry

Marquette University

Hand 1144, 3:30 PMchae yi


Abstract: One of the most urgent challenges in contemporary chemical research centers on the development of green catalytic processes that give desired products efficiently without forming wasteful byproducts. We discovered a number of selective catalytic C-H coupling methods of alkenes and arenes with alcohols that form water as the only byproduct. The analogous coupling reaction of amino acids with ketones led the expedient formation of the C-C coupling products. The hydrogenolysis of carbonyl compounds have also been achieved by ligand-modified Ru-H catalysts. These catalytic methods employ readily available substrates, form a library of biologically active products, and liberate only water and ammonia as the byproducts. This seminar will present the scope and mechanistic studies on these catalytic coupling methods.

Bio: Professor Yi received his B.S. degree from the University Michigan-Ann Arbor in 1987 and Ph.D. from the University of Wisconsin-Madison in 1991 under the direction of Prof. Charles Casey. After completing a postdoctoral training at the Pennsylvania State University (1992-93), he started his independent career at Marquette University in 1993, where he is currently appointed as the Wehr Professor.

The University of Michigan-Ann Arbor     B.S. Chemistry                               1987
University of Wisconsin-Madison             Ph.D. Inorganic Chemistry             1991
     Thesis advisor: Dr. Charles P. Casey
Pennsylvania State University                   Postdoctoral Associate                  1992-1993
Research advisor: Dr. Gregory L. Geoffroy

Assistant Professor             Marquette University, Milwaukee, WI                  1993-2000
Associate Professor            
Marquette University, Milwaukee, WI                                                            2000-2011
Marquette University, Milwaukee, WI                                                            2011-present
Wehr Professor                  
Marquette University, Milwaukee, WI                                                            2015-2018

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