Nickel-Mediated Alkyne and Amine Transformations for Greener Catalysis

Friday, October 25, 2019

Dr. Pingjin Zhao

Department of Chemistry & Biochemistry

North Dakota State

Alkynes and amines are ubiquitous small-molecule building blocks in modern chemical synthesis. In particular, their diverse interactions with transition metal complexes make them attractive targets in metal-catalyzed transformations. In this presentation Dr. Zhao will describe his group’s recent studies on nickel-mediated stoichiometric and catalytic transformations of alkynes and amines towards synthetic applications. Compared to existing methods using precious metal-based catalysts, these new catalytic reactions provide distinctive benefits of using earth-abundant nickel catalyst, high atom efficiency, and significantly reduced energy inputs that contribute to the advancement of green chemistry. The unique features of current catalytic systems are attributed to novel reaction pathways via ligand-enabled nickel interactions with alkyne and amine molecules for selective and low-energy substrate activations.

Pinjing Zhao grew up in the city of Hangzhou, China and received his BS degree in chemistry from Peking University. He came to USA for graduate research at Cornell University, working with Professor David B. Collum to study the structures and reaction mechanisms of organolithium compounds. After earning the PhD degree, he joined Professor John F. Hartwig’s group in Yale University as a postdoctoral research associate and moved with the group to University of Illinois, Champaign-Urbana, where he studied rhodium-mediated organometallic transformations. In 2007 he started his independent academic career North Dakota State University and is now an Associate Professor there. His research at NDSU focuses on transition metal-based reaction mechanism studies and homogeneous catalysis development that aims at synthetic applications in materials development and medicinal chemistry. His group's research has been supported by NSF, NIH and ND EPSCoR. Dr. Zhao is a recipient of the Thieme Chemistry Journal Award in 2010.

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