Multimerization Inhibitors of HIV-1 Integrase

Friday, January 10, 2020

Dr. Jacques Kessl

Department of Chemistry and Biochemistry

The University of Southern Mississippi

Reception: Hand 1130 at 3:00 PM

Seminar: Hand 1144 at 3:30 PM

Abstract: HIV-1 Integrase is a viral enzyme that is essential for the replication of HIV-1. Recent studies have highlighted the vulnerability of the virus to a new class of integrase inhibitors capable of disabling this viral enzyme by triggering its abnormal multimerization at several critical stages of the virus life cycle. In order to better understand the molecular and mechanistic mode of action of these compounds, we combine several approaches such as protein biochemistry, medicinal chemistry and virology.

Bio: Dr. Kessl has obtained is PhD in Biochemistry at the University of Provence in 1998. He did his post-doctoral studies at Dartmouth College working several years on drug resistance in Plasmodium. He then moved to the Ohio State University as an assistant research professor where he became an expert in the field of HIV integrase. Dr. Kessl has received several competitive NIH grants and joined the department of Chemistry and Biochemistry at the University of Southern Mississippi in August 2016.

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