Insights into Metalloenzyme Function from Bio-inspired Manganese Complexes

Friday, October 12, 2018

Dr. Timothy Jackson

Department of Chemistry

University of Kansas

Hand Lab 1144; 3:30 PMtim jackson


Abstract: Redox-active manganese enzymes participate in vital biological processes, including the defense against free radicals, the oxidation of aromatic substrates, and the conversion of nucleotides to deoxynucleotides. In many cases, these enzymatic reactions are initiated through the activation of dioxygen, or one of its reduced derivatives (superoxide or hydrogen peroxide), by an active-site manganese(II) center. While peroxo- and oxo-manganese species are commonly proposed as intermediates in these processes, the fleeting nature of these intermediates prevents a detailed understanding of geometric and electronic contributions to reactivity. This presentation will describe our on-going efforts to provide insight into these intermediates by examining the spectroscopic properties and reactivity of bio-inspired manganese complexes. A particular focus of the talk will be recent kinetic, spectroscopic, and computational investigations aimed at understanding the properties and reactivity of hydroxo- and oxo-manganese complexes.



Bio: Tim Jackson grew up in Portage, WI. He obtained his B.S. degree in chemistry from St. Cloud State University, where he performed undergraduate research on sol–gel-doped glasses in the lab of Professor Donald Neu. It was during his Ph.D. work in the lab of Professor Thomas Brunold at the University of Wisconsin—Madison that he gained his love for the rich spectroscopic properties of Mn centers. After completing work as an NIH postdoctoral fellow in the lab of Professor Lawrence Que Jr. at the University of Minnesota, he began his independent career at the University of Kansas (KU) in 2007. During his time at KU, he has won the Chancellor’s Silver Anniversary Teaching Award and the Mortar Board Outstanding Educator Award. In 2010, he was the recipient of a National Science Foundation CAREER award. He is currently a Professor of Chemistry and Faculty Fellow of the University Honors Program.

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