Functional Supramolecular Systems Based on Host-Guest Interactions and Nucleic Acid Chemistry

Friday, April 6, 2018

Dr. Janarthanan Jayawickramarajah


Tulane University

Hand 1144, 3:30 PMJJ

Abstract:  This seminar will detail how supramolecular and nucleic acid chemistries can be combined to generate functional constructs. The first section of the seminar will focus on our recent efforts on assembling multi-chromophore containing nanoarchitectures (such as nanowires, nanospheres, and thin films) with a particular emphasis on the host-guest and nucleic acid chemistry of porphyrin-containing systems. The second portion of the seminar will discuss the development of DNA small-molecule chimeras (DCs) that can bind to protein targets in response to specific biological inputs.

Bio:  Janarthanan Jayawickramarajah was born on November 15, 1977 in Kandy, Sri Lanka. He received his BS degree, with honors, in chemistry and a minor in anthropology from the University of North Carolina at Chapel Hill in 2000. In his graduate studies, he worked with Professor Jonathan L. Sessler at the University of Texas at Austin. After completion of his Ph.D. degree in 2005, he did a postdoctoral stint at Yale University with Professor Andrew D. Hamilton. In August 2007 he joined the Faculty at Tulane University, New Orleans. He is currently a Professor of Chemistry and is a Member of the Tulane Cancer Center and the Tulane Vector Borne Infectious Diseases Research Center. His research focuses broadly on biological and materials aspects of supramolecular chemistry and molecular recognition. His major contributions to these fields relate to the construction of functional and dynamic assemblies in water. In particular, he has pioneered the development of “smart” inhibitors of protein targets, based on DNA-small molecule chimeras, that are activated by disease-associated biological stimuli (funded by the US National Institutes of Health, NIH, R01 grant).1-5 Further, he has constructed photonic nano-architectures, including thin films, nanospheres, and nanowires, by self-assembling porphyrins and other complementary chromophores using inter alia host-guest chemistry (funded by the US National Science Foundation, NSF).6-10 His awards include a Doctoral New Investigator Award from the American Chemical Society PRF (2010) and an Outstanding Achievement Award from Tulane University (2014). He routinely serves on multiple NIH and NSF grant review panels and gives invited presentations at international conferences.

(1) Zhou, X. et al., J. Am. Chem. Soc. 2017, 139, 13916-13921. (2) Chu, X. et al., Bioconjugate Chemistry, 2015, 26, 8,1601-1612. (3) Su, X. et al., Chem Comm. 2015, 51,13615-13618. (4) Harris, D. C. et al., J. Am. Chem. Soc. 2011, 133, 7676-7679. (5) Harris, D. C. et al., J. Am. Chem. Soc. 2008, 130, 14950-14951.

(6) Aryal, et al., Chem Comm. 2016, 52, 2307-2310. (7) Zhu, M. et al., Langmuir, 2015, 31, 578-586. (8) Zhang, H. et al., Chem. Comm. 2014, 50, 4853-4855. (9) Zhang, N. et al., Langmuir, 2013, 29, 10796-10806. (10) Fathalla, M. et al., J. Am. Chem. Soc. 2010, 132, 9966-9967.

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