Controlling the Polymerization of Polyethyleneimine-like Polymers

Friday, November 13, 2020


Dr. Paul A. Rupar

Department of Chemistry and Biochemistry

The University of Alabama

Location: Hand 1100

Time: Nov. 13th at 4:45 PM

Abstract:  This talk will overview our work on the controlled polymerization of polyethyleneimine (PEI) and PEI like polymers.  PEI, a polymer with a -CH2CH2N(H)- repeat unit, is used in a wide variety of applications such as gene transfection, gas absorption/purification, and removal of metals from waste.    However, the synthesis of PEI is difficult to control, and great efforts are being made to improve upon its polymerizations.    We will demonstrate that the judicial selection of N-protecting groups enables the living anionic ROP of N-functionalized aziridines and subsequent conversion to linear PEI.  

“Anionic Ring-Opening Polymerization of N-(tolylsulfonyl)azetidines To Produce Linear Poly(trimethylenimine) and Closed-System Block Copolymers.” Reisman, L.; Rowe, E. A.; Jackson, E. M.; Thomas, C.; Simone, T.; Rupar, P. A. J. Am. Chem. Soc. 2018, 140, 15626-15630.

“Activated Monomer Polymerization of an N-Sulfonylazetidine”  Reisman, L.; Rowe, E. A.; Jefcoat, J. A.; Rupar, P. A. ACS Macro Lett, 2020, 9, 334-338.

Bio: Paul received his PhD from the University of Western Ontario (Canada).  His doctoral work was supervised by Prof. Kim Baines and focused on the synthesis of neutral and cationic complexes of germanium(II).   Paul’s postdoctoral work in the group of Prof. Ian Manners at the University of Bristol (UK) involved the synthesis of organometallic block copolymers and their self-assembly into complex nanostructures.  In the fall of 2012, Paul joined the Department of Chemistry at University of Alabama as a new faculty member.  Paul’s current research interests are at the intersection of polymer synthesis and inorganic chemistry.


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