Chemical Strategies to Combat Anitbacterial Resistance

Friday, February 10, 2017


Dr. Carol Taylor

Department of Chemistry

Louisiana State University

Dr. Carol TaylorA major challenge facing the world is the ability of microorganisms to become resistant to drugs in clinical use.  This talk will describe two projects that address this problem.  Firstly, a dual ligand inhibitor for acetyl Co-A carboxylase will be described.  This enzyme complex is the first committed step in fatty acid biosynthesis and is quite different in prokaryotes and eukaryotes, presenting a potential therapeutic target. Secondly, our progress toward the chemical synthesis of the microbisporins will be described.  The microbisporicins are 24-amino acids lantibiotic peptides with five thioether bridges and a C-terminal aminovinyl cysteine (AviCys) moiety.  They are the most potent lantibiotics isolated to-date.

 

Carol Taylor received her BSc in 1987, and her MSc in 1988 from the University of Auckland, New Zealand.   She received her PhD in 1993 from the University of Pennsylvania (USA) under the direction of Professor Ralph Hirschmann and Professor Amos B. Smith, III.  From 1993 to 1994, Carol was a Research Associate at Princeton University (NJ, USA) with Professor Dan Kahne.  In 1995, she returned to New Zealand to the position of Lecturer at the University of Auckland where she was awarded continuation of appointment in 1998 and promoted to Senior Lecturer in 1999.  In April 2000, she moved to Massey University in Palmerston North, New Zealand.  In 2001, she received the RSC/NZIC Easterfield Award for original contributions by a New Zealand chemist under the age of 35 and was promoted to Associate Professor in 2003.  In July 2006, she returned to the USA as an Associate Professor at Louisiana State University in Baton Rouge and was promoted to Full Professor in 2012.  Her research program is primarily engaged with the chemical synthesis and physical characterization of novel peptide motifs that arise via post-translational modifications.


Click here to view more Seminars