July 31, 2017
We would like to congratulate Dr. Xin Cui and his group on the acceptance of their first MSU publication! Below is the abstract and a link to veiw the full publication.
Catalytic [2 + 2 + 2] cycloaddition with indium(III)-activated formaldimines: a practical and selective access to hexahydropyrimidines and 1,3-diamines from alkenes
Hui Zhou,a Hetti Handi Chaminda Lakmal,a Jonathan M. Baine,a Henry U. Valle,a Xue Xua and Xin Cui
Catalytic [2 + 2 + 2] cycloaddition with imines has, for the first time, been developed as a practical and selective approach for direct construction of hexahydropyrimidine derivatives from various alkenes. With formaldimines as reagents and simple InCl3 as the catalyst, this ionic [2 + 2 + 2] approach is applicable for a wide scope of alkenes and allenes with various electronic and steric properties, as well as substitution patterns. Through facile hydrolysis of the resulting hexahydropyrimidines, this catalytic process also provides a new synthetic strategy for the aminomethylamination of alkenes and allenes to practically access 1,3-diamine derivatives.
Click here to view more news & events.