Acceptance of First MSU Publication for Dr. Cui and Group

July 31, 2017

10:15 am


TOC

We would like to congratulate Dr. Xin Cui and his group on the acceptance of their first MSU publication!  Below is the abstract and a link to view the full publication. 

Catalytic [2 + 2 + 2] cycloaddition with indium(III)-activated formaldimines: a practical and selective access to hexahydropyrimidines and 1,3-diamines from alkenes

Hui Zhou, Hetti Handi Chaminda Lakmal, Jonathan M. Baine, Henry U. Valle, Xue Xu, and Xin Cui

Chem. Sci. 2017, 8, 6520-6524.

Abstract

Catalytic [2 + 2 + 2] cycloaddition with imines has, for the first time, been developed as a practical and selective approach for direct construction of hexahydropyrimidine derivatives from various alkenes. With formaldimines as reagents and simple InCl3 as the catalyst, this ionic [2 + 2 + 2] approach is applicable for a wide scope of alkenes and allenes with various electronic and steric properties, as well as substitution patterns. Through facile hydrolysis of the resulting hexahydropyrimidines, this catalytic process also provides a new synthetic strategy for the aminomethylamination of alkenes and allenes to practically access 1,3-diamine derivatives.

http://doi.org/10.1039/C7SC02576A


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