Acceptance of First MSU Publication for Dr. Cui and Group

July 31, 2017

10:15 am


We would like to congratulate Dr. Xin Cui and his group on the acceptance of their first MSU publication!  Below is the abstract and a link to veiw the full publication. 

Catalytic [2 + 2 + 2] cycloaddition with indium(III)-activated formaldimines: a practical and selective access to hexahydropyrimidines and 1,3-diamines from alkenes

Hui Zhou,a  Hetti Handi Chaminda Lakmal,a  Jonathan M. Baine,a  Henry U. Valle,a  Xue Xua  and  Xin Cui

Abstract

Catalytic [2 + 2 + 2] cycloaddition with imines has, for the first time, been developed as a practical and selective approach for direct construction of hexahydropyrimidine derivatives from various alkenes. With formaldimines as reagents and simple InCl3 as the catalyst, this ionic [2 + 2 + 2] approach is applicable for a wide scope of alkenes and allenes with various electronic and steric properties, as well as substitution patterns. Through facile hydrolysis of the resulting hexahydropyrimidines, this catalytic process also provides a new synthetic strategy for the aminomethylamination of alkenes and allenes to practically access 1,3-diamine derivatives.

http://pubs.rsc.org/en/content/articlelanding/2014/SC/C7SC02576A#!divAbstract


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